I agree to an extent and that is why when you design that little bit bigger you make sure that content is not out of the 780 pixel width that is displayed in 800px width monitors so you do not lose visitors completely. If the user on a smaller resolution misses secondary links and some advertising in the right hand column then so be it.
Also take into account real-world stats for your site if you can, for example this site gets several hundred thousand page views per month but only gets 3.11% of traffic at 800x600.
Also take a peek at the BBC these days - what width is their home page?
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